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Mulberry bush. Research studies in China and Japan are portraying mulberry powder or mulberry leaf extract as inhibitors of enzymes that otherwise turn loose glucose in the blood. Food scientists are in agreement that the mulberry plant is medicinal. One recent study published in the Diabetes Care journal reported that a mulberry leaf extract reduced peak post-meal blood sugar spikes by 44 percent, on average. 

One suggested interim approach for mulberry is to purchase a mulberry leaf extract in a 30-to-1 concentrate standardized to contain two percent moranoline content. Pharmacopoeia of the Heavenly Husbandman, the first written documentation of Chinese herbal medicine (dating back to 200 B.C.), called mulberry leaf the "Divine Leaf" because of its healing and anti-aging power. 

Later, the Grand Materia Medica (or Compendium of Materia Medica), written in the 16th century, and the most authoritative classic Chinese herbal textbook, also described mulberry leaf as the "Divine Leaf," saying "It can be boiled to drink as tea, and if taken often can promote beauty and strength digestion. Take the extract twice daily. Mulberry leaves are grown in the deep mountains of Southeast China, harvested in late August, and only leaves on the distal parts of younger branches are picked to ensure the active ingredients are at their richest. A proprietary extraction method is then applied to prepare the final ingredient.

Benefits of  Mulberry in Our Diabetic Boost

Nacide Ercan-Fang, MD, Litao Zhong MD, PHD3 Julie Furne and Michael Levitt, MD Says about about Mulberry:  Click for more info

Mulberry Leaf ExtractMulberry Leaf as Human Food

Srivastava S, Kapoor R, Thathola A, Sriyastaya RP. Mulberry (Morus alba) leaves as human food: a new dimension of sericulture. Int J Food Sci Nutr. 2003 Nov;54(4):411–6.

Mulberry Leaves as Antioxidants and Neuroprotective Agents

Niidome T, Takahashi K, Goto Y, Goh S, Tanaka N, Kamei K, et al. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport. 2007 May 28;18(8):813–6.

Kang TH, Oh HR, Jung SM, Ryu JH, Park MW, Park YK, Kim SY. Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol Pharm Bull. 2006 Feb;29(2):270–4.

Tewari RK, Kumar P, Sharma PN. Antioxidant responses to enhanced generation of superoxide anion radical and hydrogen peroxide in the copper-stressed mulberry plants. Planta 2006 May;223(6):1145–53. Epub 2005 Nov 15.

Choi EM, Hwang JK. Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. Fitoterapia. 2005 Dec;76(7-8):608–13. Epub 2005 Oct 17.

Sharma R, Sharma A, Shono T, Takasugi M, Shirata A, Fujimora T, Machii H. Mulberry moracins: scavengers of UV stress-generated free radicals. Biosci Biotechnol Biochem. 2001 Jun;65(6):1402–5.

Mulberry Leaf in Lowering Lipidemia and Improving Blood Vessel Health

Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice.Asia Pac J Clin Nutr. 2007;16 Suppl 1:290–4.

Harauma A, Murayama T, Ikeyama K, Sano H, Arai H, Takano R, et al. Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2007 Jul 6;358(3):751–6. Epub 2007 May 7.

Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M, Yamane Y.Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr. 2005 Apr;135(4):729–34.

Doi K, Kojima T. and Fujimoto Y. Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein. Bio Pharm Bull. 2000 Sep;23(9):1066–71.

Mulberry Leaf and Blood Sugar Management

Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food. 2007 Mar;10(1):41–8.

Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem. 2007 Jul 11;55(14):5869–74. Epub 2007 Jun 8.

Mudra M, Ercan-Fang N, Zhong L, Furne J, Levitt M. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care. 2007 May;30(5):1272–4. Epub 2007 Feb 15.

Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia. 2006 Dec;77(7-8):568–73. Epub 2006 Sep 22.

Oku T, Yamada M, Nakamura M, Sadamori N, Nakamura S. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr. 2006 May;95(5):933–8.

Hu ML, Wang RJ. Antioxidant role of mulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta. 2004 Oct;348(1-2):215; author reply 217-8. [No abstract available.]

Miyahara C, Miyazawa M, Satoh S, Sakai A, Mizusaki S. Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. J Nutr Sci Vitaminol (Tokyo). 2004 Jun;50(3):161–4.

Murata K, Yatsunami K, Fukuda E, Onodera S, Mizukami O, Hoashino G, Kamei T. Antihyperglycemic effects of propolis mixed with mulberry leaf extract on patients with type 2 diabetes. Altern Ther Health Med. 2004;10:78–9.

Sakuramata Y, Oe H, Husano S, Aki O. Effects of combination of Caiapo with other plant-derived substance on anti-diabetic efficacy in KK-Ay mice. Biofactors. 2004; 22:149–52.

Andallu B, Varadacharyulu NCh. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta. 2003 Dec; 338(1-2):3–10.

Andallu R, Varadacharyulu NCh. Control of hyperglycemia and retardation of cataract by mulberry (morus indica L.) leaves in streptozotocin diabetic rats. Indian J. Exp Biol. 2002; 40:791–5.

Andallu B, Suryakantham V, Lakshmi SB, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta. 2001; 314: 47–53.

Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric Food Chem. 2001; 49:4208–13.

Taniguchi S, Asano N, Tomino F, Miwa I. Potentiation of glucose-induced insulin secretion by fagomine, a pseudo-sugar isolated from mulberry leaves. Horm Metab Res 1998; 30:679–83.

Asano N., Oseki K, Tomioka E, Kizu H, Matsui K. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res. 1994; 259:243–55.

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